Excess iodine can cause goiter, thyroid inflammation, hypothyroidism, or thyrotoxicosis, and case literature shows Lugol's solution can trigger thyroiditis in susceptible people. The American Thyroid Association has advised against iodine or kelp supplements above 500 mcg per day because of excess-iodine risk. Extra caution is especially important for people with Hashimoto's thyroiditis, Graves' disease, thyroid nodules, unexplained thyroid symptoms, or anyone taking levothyroxine, antithyroid drugs, amiodarone, or lithium. Pregnancy, lactation, infants, and children are also groups where iodine needs and safety have to be balanced carefully, ideally with clinician guidance.2349121314